Which of the findings of the human genome project were contrary to initial expectations?.

Answers

Answer 1

Answer:

Which of the findings of the Human Genome Project were contrary to initial expectations? -The human genome contains fewer than 21,000 genes.

Explanation:

Answer 2

Less than 21,000 genes make up the human genome. Human genes with many exons have alternatively spliced variants in 93% of cases.

What is genome?

Genome is defined as the entirety of a cell's DNA instructions.One small chromosome that is found in the mitochondria and 23 pairs of chromosomes that are present in the cell's nucleus make up the human genome. The genome is made up of all the DNA instructions that are present in a cell. One small chromosome that is found in the mitochondria and 23 pairs of chromosomes that are present in the cell's nucleus make up the human genome.

The first sequence of the human genome was the main goal of the Human Genome Project, a massive multinational scientific endeavor. The experiment demonstrated that human genomes are 99.9% identical, which paved the way for compiling a list of human genes and starting to comprehend the intricate dance involved in gene regulation.

Thus, less than 21,000 genes make up the human genome. Human genes with many exons have alternatively spliced variants in 93% of cases.

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Related Questions

imagine a transmembrane molecule that lies in the plasma membrane and acts as a receptor for an extracellular signaling molecule. when the ligand-binding domain is inserted into the er during synthesis of this transmembrane molecule, will it lie on the lumen side of the er or the cytoplasm side?

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It will be on the lumen side of the ER when a ligand binding domain is incorporated into the ER during production of the transmembrane protein lying in the plasma membrane.

What three purposes serve the plasma membrane?

The cell is shielded from its surroundings by the plasma membrane, which also controls cellular movement and sends messages. According to the fluid mosaic model, phospholipids are arranged in a mosaic to form the plasma membrane.

Where does the plasma membrane reside?

The outer layer of a live cell, also known as the plasma membrane, encloses the cytoplasm and nucleus. It is a membrane with selective permeation. A cell wall exists outside of the cell membrane in bacteria and plant cells. Animal cells have cell walls that contain the cell membrane.

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In organisms that have two different alleles for a gene, if only one of them is needed to express the phenotype then that allele is said to be.

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Since only one copy is required to express the allele, it will be referred to as dominant.

There are dominant and recessive alleles. An organism will express the dominant phenotype if it is heterozygous at a particular locus and carries both a dominant and recessive allele. Such type of allele need only one copy to be able to express their phenotype. Disease carried by dominant need only one allele to affect the organism.

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What is the difference between an inhibitory and an excitatory post synaptic potential?.

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Although the details of postsynaptic action can be complex, there are simple rules that distinguish between postsynaptic excitation and inhibition.

EPSPs have reversal potentials more positive than the action potential threshold and IPSPs have reversal potentials more negative than the threshold.Excitatory postsynaptic potentials (EPSPs) bring the potential of a neuron close to its firing threshold. Inhibitory postsynaptic potentials (IPSPs) shift the charge across the membrane away from the firing threshold. Postsynaptic potentials undergo spatial and temporal addition. Neurons communicate via electrical currents called action potentials that are either excitatory or inhibitory. Currents responsible for sharing information about one action potential with the next neuron, inhibitory currents reduce the likelihood of such transmission occurring.

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atp is considered a high-energy molecule. when atp undergoes hydrolysis to adp, how much energy is produced?

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One ATP molecule's hydrolysis releases 7.3 kcal/mol - energy (G = 7.3 kcal/mol of power).

What is referred to as bio energy?

A variety of resources, including bioenergy, are available to assist us meet our need for energy. It is a type of renewable energy produced from different kinds of living organic matter, or biomass, which can be utilized to create products, heat, power, and transportation fuels.

What purposes serve bioenergy?

The term "bioenergy" refers to the use of organic material (biomass) as an energy source for power (or electricity) generation and straightforward origin heat applications in all energy sectors, including for domestic, commercial, and industrial purposes as well as the creation of liquid fuels for transportation.

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The backbone of DNA consists of ______.
a) paired nucleotides
b) a repeating sugar-nucleotide-sugar-nucleotide pattern
c) nitrogenous bases
d) a repeating sugar-phosphate-sugar-phosphate pattern

Answers

The backbone of DNA is made up of a sugar-phosphate-sugar-phosphate pattern that repeats itself.

What is the structure of DNA?DNA is a nucleotide-based double helical structure. Hydrogen bonds hold the two helices together. A sugar-phosphate backbone is also present in the DNA.Nucleotides are the building blocks of DNA and are composed of three components: a deoxyribose (5-carbon sugar), a phosphate group, and a nitrogenous base.A double helix is a twisted ladder-like structure composed of two interconnected strands winding around each other. Each strand has a sugar (deoxyribose) and phosphate backbone that alternates. Each sugar is connected to one of four bases: adenine (A), cytosine (C), guanine (G), or thymine (T).Understanding the structure and function of DNA has revolutionized disease pathway research, assessing an individual's genetic susceptibility to specific diseases, diagnosing genetic disorders, and developing new drugs. It is also essential for pathogen identification.

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the process of introducing a dead pathogen or nontoxic part of a pathogen into the body to provoke an immune response that prevents a certain disease is called

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The process of introducing a dead pathogen or nontoxic part of a pathogen into the body to provoke an immune response that prevents a certain disease is called Vaccination .

Vaccination is the process of administering a vaccine to aid the immune system in developing immunity to a disease. Vaccines contain a weakened, live, or killed microorganism or virus, as well as proteins or toxins from the organism.

Vaccination is a simple, secure, and effective way to safeguard yourself against potentially fatal diseases before being exposed to them. It strengthens your immune system by utilizing your body's own natural defenses to build resistance to specific infections.

Vaccines assist your body to produce protective antibodies, which are proteins that help your body fight infections. By getting vaccinated, you can protect yourself while also preventing the spread of preventable diseases to others in your community.

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bicoid is a gene that produces a porphogen. what results when there is a high concentration of the bicoid protein in a devlopoing [mebryo

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A high concentration of bicoid protein at the opposite ends of a developing Drosophila embryo would result in the development of a two-headed fly.

Bicoid acts as a morphogen during Drosophila development. Thus, BCD mRNA is maternally located at the anterior pole of the embryo and Bcd forms an anterior/posterior gradient that functions in a concentration-dependent manner. Both functions require a homeodomain that recognizes.

DNA motifs on target gene enhancers and specific sequence spacing of her 3 untranslated regions of the tail mRNA. Female embryos with the bicoid mutation lack the head and thorax replaced by a posterior telson. Embryos lacking both maternal and zygotic hb show reduced and anterior shifts of ems and btd expression at the blastoderm stage.

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Two plants are heterozygous for seed shape and have round seeds. If the two plants are crossed, what is the probability that the offspring will have wrinkled seeds?

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Answer: 25%

Explanation: Heterozygous means that an individual has two different versions, or alleles, of a gene. In this case, one plant has an allele for round seeds and an allele for wrinkled seeds, while the other plant also has an allele for round seeds and an allele for wrinkled seeds. When these two plants are crossed, each offspring will inherit one allele for seed shape from each parent.

The probability that an offspring will have wrinkled seeds is determined by the proportion of offspring that inherit the allele for wrinkled seeds from both parents. If both parents are heterozygous, this means that each parent has a 50% chance of passing on their allele for wrinkled seeds to their offspring. Therefore, the probability that an offspring will inherit the allele for wrinkled seeds from both parents is (0.5)(0.5) = 0.25, or 25%. This means that the probability that an offspring will have wrinkled seeds is 25%.

Answer:

A

Explanation:

just trust me bro

Which of the following statements accurately describes the difference between cellular and humoral immunity?
Cellular immunity directly attacks pathogens and infected cells, while humoral immunity releases antibodies to do so
Cellular immunity utilizes B-lymphocytes, while humoral immunity utilizes T-lymphocytes
Cellular immunity produces antibodies, while humoral immunity uses perforins
Neither defends against bacteria

Answers

While humoral immunity produces antibodies to do this, cellular immunity assaults pathogens and infected cells directly.

What distinguishes cellular immunity from humoral immunity?The primary distinction between humoral and cell-mediated immunity is the production of antigen-specific antibodies by humoral immunity as opposed to cell-mediated immunity.T lymphocytes, on the other hand, cause apoptosis in infected cells to cause their death.B Cells produce antibodies during humoral immunity reactions after becoming activated by free antigens found in bodily fluids.T cells attack infected body cells that have pathogen antigens on their surface during cell-mediated immune responses.Humoral immunity is an adaptive immune response that is exhibited by the B cells' generation of antibodies.It grows in the bone marrow.Plasma cell development in B cells may be induced.A plasma cell makes an antibody.When the B cell receptor and the antigen interact, antibodies are created.

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of the different factors that affect transpiration rates, which are negatively correlated with transpiration rate? choose all that apply.

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Transpiration is affected by several factors. In the above question, the factor which affects transpiration negatively is Humidity, i.e. Option 1.

The process by which the plant body releases water vapors through its aerial portions is known as transpiration. The evaporation of water from a plant component is also referred to as transpiration. It is a key mechanism in plants that helps other processes and maintains water and nutrient balance.

The rate of transpiration is inversely related to the humidity of the atmosphere.

Stomata only open when there is light. As a result, transpiration is greatest during the day and lowest at night.

When soil moisture is less, roots absorb less water from the earth. As a result, the stomata close and the plant wilts. As a result, the rate of transpiration is reduced.

Therefore, humidity is the factor which affects transpiration negatively. The correct answer is option 1.

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The correct question is:

Of the different factors that affect transpiration rates, which are negatively correlated with transpiration rate? Choose all that apply.

1. Humidity

2. Light

3. Soil moisture

4. None

Which four individual muscles make up the quads in the anterior femoral region of the leg?.

Answers

Four individual muscles make up the quads in the anterior femoral region of the leg are. Rectus femoris, Vastus lateralis, Vastus medialis and Vastus intermedius .

Rectus femoris is attached to the hip and helps to extend or raise the knee. Vastus lateralis, is the largest part of the quadriceps femoris, a muscle in the thigh. Four muscles in quad group helps to straighten your knee the rectus femoris, the vastus intermedius, the vastus lateralis, and the vastus medialis.

Only biceps femoris is not a member of the quadriceps and is actually an antagonist muscle found on the posterior leg.

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The ________ are rope-like connections between muscles and bones and result from the fusion of periosteum with the connective tissue of muscle.

Answers

Answer:

Tendon

Explanation:

Tendon is a type of connective tissue that connects muscle to bone. The ligament is a connective tissue connecting bones to other bones. Cartilage is one of the types of connective tissue which covers the ends of bones at the joint.

What processes happen within your nervous system to you to pull your finger away before you even think about it?

Answers

Reflexes. Your pain receptors will feel pain and immediately send a message to your brain to not touch it since it hurts.

The process is called reflex action when your nervous system does you to pull your finger away before you even think about it.

What is reflex action?

A sudden, reflexive response to stimuli is known as a reflex action. It aids organisms in making a fast adjustment to a bad situation that could otherwise result in physical injury or even death.

A typical reflex action is pulling our hands away right away after touching something that is hot or cold. Your brain receives an immediate signal from your pain receptors telling it to stay away from the painful area.

These acts are performed by motor neurons, which move your hand or activate the heart muscles. The peripheral nervous system is in charge of carrying out these tasks.

Therefore, when your nervous system causes you to move your finger away before you even think about it, the process is known as a reflex action.

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What effects does a dysfunctional nervous system have on other systems of the body? Provide at least one specific example.

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A dysfunctional nervous system has many effects on other systems.

The nervous system is a system that carries out some critical functions.  It sends messages through the entire brain and the body. The brain controls all the functions in the human body, without which the body will shut.

A dysfunctional nervous system can affect every part of the human body. this includes disfunction of any part, weakness, and low functioning ability of the body or certain parts. This can eventually lead to the death of the person.

Problems like mood swings, depression, anxiety, etc, normally occur due to a dysfunctional nervous system.  

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Which division of the autonomic nervous system returns the body to a relaxed condition after an emergency?.

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Explanation:

The parasympathetic nervous system is responsible for the body's rest and digestion response when the body is relaxed, resting, or feeding. It basically undoes the work of sympathetic division after a stressful situation. The parasympathetic nervous system decreases respiration and heart rate and increases digestion.

Climate scientists use numerical climate __________ to project the future climate.

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Climate scientists use numerical climate model to project the future climate.

Climate models are computer programmes that scientists use to study how our planet is evolving and forecast future climate. Computerized climate models operate similarly to a laboratory. They let researchers to examine how several variables combine to affect a region's climate.

Numerical climate models study the interactions of the major climatic drivers, such as the atmosphere, seas, land surface, and ice, using quantitative methodologies. They serve a number of functions, from studying the dynamics of the climate system to making climate forecasts.

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describe the manner in which activators and repressors influence the rate of transcription initiation. how might chromatin structure be involved in such regulation?

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Activators and repressors change the relationship of RNAP II to the transcription complex and DNA loops bring distant enhancer or silencer elements in proximity with promoter regions of the genes.

How does activators and repressors influence the rate of transcription initiation?

Transcription boost transcription of genes. Repressors decrease the transcription. Groups of transcription factors binding the sites that are called enhancers and silencers can turn a gene on/off in specific parts of the body.

Activators and repressors regulate transcription in eukaryotes by interacting with general transcription factors and other components of the transcriptional machinery and also by inducing changes in the structure of chromatin.

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if mendel crossed a pea plant homozygous dominant for yellow peas (yy) with a homozygous recessive plant with green peas (yy), what percentage of offspring will be homozygous dominant?

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The percentage of offspring of homozygous dominant will be 50%.

Gregor Mendel, the Father of Genetics, utilised pea plants as a model to study inheritance for a variety homozygous of reasons, the most important of which is that they have a wide range of phenotypic features, such as diverse colours and shapes.

Mendel studied the inheritance patterns of parental genes in terms of how these genetic qualities homozygous manifested in the phenotype of the children, and he classified these traits as dominant (two capital letters; AA) or recessive (one capital letter; AA). He used yellow and green pea plants to test this in the trials. When he crossed yellow and green pea plants, he discovered that the first generation was yellow. This meant that the colour yellow (YY) was dominant, while the colour green (YY) was recessive.

Therefore, the percentage of offspring of homozygous dominant will be 50%.

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which statement is false about the skeletal alterations caused by chronic renal failure? when the glomerular filtration rate (gfr) declines to 25% of normal

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A adequate amount of parathyroid hormone can no longer be secreted by the parathyroid gland .

GFR declines when the macula densa notices an increase in the concentration of NaCl in the renal filtrate.By monitoring filtrate osmolarity, the macula densa controls the body's blood pressure. If it falls too low, it causes the kidney's afferent arterioles to constrict, increasing pressure at the glomerulus and increasing glomerular filtration rate.Increased sodium chloride supply to the macula densa causes the production of adenosine, which causes vasoconstriction when it binds to the afferent arteriole. GFR is reduced as a result of the vasoconstriction.

It is thought that the distal tubule fluid's sodium content and maybe the speed at which the fluid passes through them cause the macula to react.

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polypeptides in the er are usually larger than polypeptides synthesized from the same mrna that have not entered the er.

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Polypeptides in the er are usually larger than polypeptides synthesized from the same mrna that have not entered the er.

Hence, the above statement is True

The size of polypeptides inside the ER is typically less than that of polypeptides made from the same mRNA but not yet inside the ER. On the rough ER, proteins for plasma membrane transmembranes are synthesised. Through a translocon, a freshly created polypeptide chain enters the ER.Peptide synthesis is primarily carried out on the rough endoplasmic reticulum (RER). By sequentially digesting transfer RNAs (tRNA) with their attached amino acids, messenger RNA (mRNA), which is encoded by nuclear DNA, is translated into peptides by cytosolic ribosomes.

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What type of chemical bond joins the bases of complementary DNA strands?
a) hydrophilic
b) covalent
c) hydrogen
d) ionic

Answers

Answer:

c) hydrogen

Explanation:

Which represents the greatest time frame in which a short term environmental change can occur
In day
In minutes
Over hundreds of years
Over thousands of years

Answers

Answer:

over hundreds of years

Explanation:

this is because a shorter time frame can allow a short environmental change to take place. This is as a result of the understanding that hundreds of years is a shorter time frame in which short term environmental changes can take place compared to thousands of years

During cellular respiration, cells break down sugars to release energy. In this process, water and carbon dioxide are produced as waste products. What must happen to these waste products in order for a cell to maintain homeostasis?.

Answers

From the cell, they must be expelled. Through the breakdown of glucose molecules and the addition of oxygen, carbon dioxide and water are produced during respiration, which releases energy.

What does the term "body homeostasis" mean?

The term "homeostasis" refers to a self-regulating mechanism that enables an organism to retain internal stability while adapting to shifting external situations. It has emerged as the key unifying idea in physiology.

Describe a straightforward instance of homeostasis.

In reaction to changes in the environment, an organism can maintain internal stability through homeostasis. Homeostasis is best shown by the body's internal temperature.

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The trp operon in e.coli regulates genes that code for enzymes required for synthesis of the amino acid tryptophan. the trp operon is a repressible operon. when tryptophan is not available in the environment, the trp repressor protein is____. therefore, rna polymerase can bind to the___to begin transcription.

Answers

It is not active to suppress trp. The promoter may so be bound by RNA polymerase, which will then start transcription.

An illustration would be genes.

Numerous characteristics, such as your skin and hair colors, are determined by the genes you inherit. The red hair gene may have been passed on to Emma by her mother, who may have two genes—one for brown hair and one for red hair. She could have red hair if her father carries two genes for the color.

The significance of genes

Your cells' growth and function are governed by instructions carried by your genes. The foundation of the body are cells. Billion of cells work together to form every component of your body. Chromosomes are the units that hold genes in place.

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Which type of process first occurred in the ecosystem around Mount St. Helens after it erupted?

Answers

Answer: Succession

Explanation: Succession that begins in an area with no remnants of an older community

label the flower. please help i’d appreciate it

Answers

Answer:

A. Ovule

B. Ovary

C. Style

D. Stigma

E. Pistil

F. Anther

G. Stamen

H. Filament

I. Sepal

J. Petal

Explanation:

I took bio alr

The products of photosynthesis required to start cellular respiration are
A.Oxygen and ATP.
B.Water and Carbon dioxide.
C.NADP and Hydrogen.
D.Glucose and Oxygen.
E.Carbohydrates and NADP.

Answers

The answer is C hope this helps

The pot with tipped over and after a while the plant stem bent and grew toward the light growing towards the Sun/light and away from the pull of gravity. Which characteristic of a living thing is this an example of?

Answers

The characteristics of living thing that the statement exemplifies is irritability.

What are living things?

Living things are such that have life in them or shows the characteristics of life or being alive.

The fundamental characteristics of life are as follows:

having an organized structurerequiring energyresponding to stimuliadapting to environmental changesbeing capable of reproductiongrowthmovementmetabolismdeath

Irritability is a natural susceptibility, characteristic of all living organisms, tissues, and cells, to the influence of certain stimuli, response being manifested in a variety of ways.

Therefore, the response of the plant to light and gravity is termed irritability.

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the anatomic makeup of which bone structures make them susceptible locations for osteomyelitis in children? (select all that apply.)

Answers

The anatomic makeup of which bone structures make them susceptible locations for osteomyelitis in children are

a). Hip joint

b). Distal femur

c). Proximal humerus

e).Lateral ankle

Osteomyelitis is a type of bone infection that is caused by bacteria. It is a rare but serious condition that can cause severe pain, swelling, and redness in the infected area. It can also lead to bone destruction, joint damage, and limb loss. Osteomyelitis can affect any bone in the body, but it is most commonly found in the long bones of the arms and legs. Treatment usually requires antibiotics and, in some cases, surgery.

Osteomyelitis in children is typically seen in the long bones of the arms and legs, such as the femur and humerus, as well as the distal radius and tibia. The hip joint and lateral ankle are also susceptible locations for osteomyelitis in children.

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. why do you think four molecules of catecholamine neurotransmitters are generally bound to each molecule of atp?

Answers

In four neurotransmitter molecules the catecholamine is bound to each molecule of ATP because the synaptic vesicles and synaptic granules on the neurotransmitter contain adenosine triphosphate with a molar ratio of catecholamine to ATP of approximately 4:1.

Hormones that play a role in the nervous system are catecholamines in the form of epinephrine (adrenaline) and norepinephrine (noradrenaline). The adrenal medulla contains chromaffin granules (organelles in cells) which function for the biosynthesis, absorption, storage, and secretion of catecholamines.

Other compounds contained in these granules are ATPMg2+, Ca2+, Dopamine-β-hydroxylase (DBH), and the protein chromogranin. Catecholamines enter the granules by a transport mechanism with an ATP-dependent ratio of catecholamines : ATP = 4 : 1. Norepinephrine is stored in the granules, can leave and undergo methylation of the N-terminal end of the protein to form norepinephrine and then enter new granules.

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A company relies on innovation as its main competitive advantage, and wants to maintain the confidentiality of its research and development projects. Which of the following is it most likely to use when hiring new staff? Select one a. Employment-at-will contracts. O b. Implicit contracts O c. Restrictive agreements O d. Non solicitation agreements Although he is best known by his pen name, Mark Twain's birth name is Samuel A Langhorne Clemens. Mark Twain was born in 1835, just after Halley's Comet, a short- B period comet visible from Earth every seventy-five years, was visible in the sky. Twain grew up on the banks of the Mississippi River in Hannibal, Missouri. His childhood C adventures with his friend's along the Mississippi River served as inspiration for his D novels, The Adventures of Tom Sawyer and The Adventures of Huckleberry Finn. One vear before his death, Twain said, "I came in with Halley's Comet in 1835. It is coming again next year (1910), and I expect to go out with it. It will be the greatest disappointment of my life if I don't go out with Halley's Comet." Just as he predicted, Twain died of a heart attack in 1910, just one day after the comet appeared in the night sky. What is the correct way to write people who Immigrated from sentence 6? A. People who Immigrated B. People who immigrated C. People Who Immigrated D. people who immigrated What is the main flora in western europe? question 16 options: a. vineyards and deep-rooted b. plants c. forests d. grasslands e. olive trees The perimeter is less than 20 meters Please help I'm desperate a company subscribing to ethical relativism would implement the morality of the . a. host country b. shareholders c. legal system d. home country at your high school reunion you cannot remember the last name of your acquaintance. your failure to remember is most likely the result of Create the following global security groups in the Users container for each administrative role: PasswordAdmins ComputerAdmins GPOLinkAdmins Use the Delegation of Control wizard to delegate the necessary permissions at the correct level to each group. In the wizard, use the common tasks option for delegating control Advantages of thermal method 1) The basic process technology is available and reasonably well developed. 2) Can be scaled to handle large volumes of liquid waste. 3) An excellent disposal method for biologically hazardous wastes. 4) Large areas of land are not required. 5) Reduction of leachability of the wastes after it is incinerated, thus making Question. {Please explain your answer}(Which statement correctly describe the data shown in the scatter plot?)A. The scatter plot shows no association.B. The scatter plot shows a linear association.C. The point (2, 14) is an outlier.D. The scatter plot shows a negative association. What the type of ad in which a broker attempts to promote or solicit real estate activity without disclosing the fact that they are a licensed real estate broker?Blind ad 8. What value of g makes the equation true? g + 4.3 = 7.2 A) 3.5 B) 2.9 C) 11.5 D) 10.1 Excerpts from Neuwirth Corporation's comparative balance sheet appear below:Ending Balance Beginning BalanceCash and cash equivalents $44,000 $ 34,000 Accounts receivable $31,000 $ 35,000 Inventory $72,000 $ 75,000 Which of the following is the correct treatment within the operating activities section of the statement of cash flows using the indirect method? In this experiment, you will prepare a standard solution for a calibration curve for the formation of FeSCN2 complex by reaction different volumes of 0.002M Fe(NO,), and 0.002 M NaSCN. You will use 0.1M HNO, for all dilutions. Using the table, Calculate the equilibrium concentrations of FeSCN2+ Vol of Fe Vol of SCN 0.1 M HNO3 (mL) Equilibrium (mL) 10.00 10.00 concentration Fe[SCN] (mL) 0.00 1.00 2.00 3.00 4.00 5.00 10.00 9.00 8.00 7.00 10.00 10.00 10.00 6.00 5.00 10.00 Experiment 12 Le Chatelier's Principle: Chemical Equilibrium and Determination of Equilibrium Constant: Pre-Lab solve the inequalitysolve for q2.01q>4.86 A small cargo plane currently has 150 pounds of cargo aboard. In addition, n boxes weighing 30 pounds each will be brought aboard.Suppose that the total weight of the cargo on board must be at most p pounds. Using the values and variables given, write an inequality describing this. If we begin from star birth, the next key stage in the star-gas-star cycle occurs when a(n) ____ returns gas and new elements into space. A car travels west 60 kilometers in 2.5 hours. Its average velocity for the trip is ____ km/h.pls help Conditions of high pressure and relatively low temperature are found in zones of subductionO TrueO. False Which element of the heros journey is depicted in this passage