The gram-negative bacterium Vibrio cholerae produces a protein, cholera toxin (Mr 90,000), that is responsible for the characteristic symptoms of cholera: extensive loss of body water and NaCl through continuous, debilitating diarrhea. If body fluids and NaCl are not replaced, severe dehydration results; untreated, the disease is often fatal. When the cholera toxin gains access to the human intestinal tract it binds tightly to specific sites in the plasma membrane of the epithelial cells lining the small intestine, causing adenylyl cyclase to undergo prolonged activation (hours or days).

a. What is the effect of cholera toxin on [cAMP] in the intestinal cells? Why?
b. Based on the information above, suggest how cAMP normally functions in intestinal epithelial cells. Briefly justify.
c. Suggest a possible treatment for cholera

Answers

Answer 1

Answer:

a.) It causes prolonged activation of adenylyl cyclase which leads to increased levels of Cyclic adenosine monophosphate(cAMP).

b.) In the intestinal epithelial cells, the cAMP binds to the apical chloride channels and allows it to open leading to osmotic permeability of water across the cell into the lumen of the intestine which is excreted through the faeces.

C.) Cholera can effectively be treated through the use of antibiotics and intravenous fluid replacement therapy.

Explanation:

Vibrio cholerae is a gram negative rigid curved bacillus that are actively ( vigorously) motion by a polar flagellation. The name vibrio is derived from the characteristic vibration movement of the organism when viewed under a microscope. This bacteria is capable of producing toxins called cholera toxin, which it uses as a virulent factor. It is responsible for the characteristic symptoms of cholera: extensive loss of body water and NaCl through continuous, debilitating diarrhea.

Cyclic adenosine monophosphate(cAMP) which is called a second messenger because it is not a hormone that can directly institute an intracellular change, instead, it serves as a second messenger to cause an effect.In the intestinal epithelial cells, the cAMP binds to the apical chloride channels and allows it to open leading to osmotic permeability of water across the cell into the lumen of the intestine which is excreted through the faeces.

In the effect of cholera toxin on the cAMP in the intestinal cells, Cholera toxin increases the fluid loss. The binding of the toxin to the intestinal cells causes a large increase in the level of cAMP in the cells by inhibiting the conversion of GTP bound to Ga to GDP. So adenyl cyclase is not turned off and diarrhea results.

The possible treatment is through the use of antibiotics and intravenous fluid replacement therapy. Prompt and adequate replacement of lost fluid and electrolyte through oral administration and supplemented with intravenous administration of fluids highly suggested for treatment of cholera. Antibiotics is equally used for treatment only when the cholera strain has been confirmed sensitive to it through culture.


Related Questions

Please help I’ll mark you as brainliest if correct

Answers

Answer:

6

Explanation:

can you heat alcohol over an open flame. Give reason for your answer​

Answers

Answer:

No, you cannot. The problem is that alcohol fumes are flammable. If you heat over an open flame you risk igniting the fumes which will start a chain reactions.

Explanation:

ggl and knowledge

7. How does distance affect the strength of an electric force?
A. Electric forces that are closer together are weaker.
B. Electric forces that are closer together are stronger.
O C. Electric forces have the same strength regardless of distance.
O D. Electric forces create their own strength depending on their charge.

Answers

The correct answer will be A
A. Electric forces that are closer together are weaker
Explanation: Increasing the separation distance between objects decreases the force of attraction or repulsion between the objects.

what do endocrine glands use as Messengers?

A. Blood
B. Hormones
C. Target Organs
D. Zygote

Answers

Answer:

b. hormones

Explanation:

"The endocrine system is made up of glands that make hormones. Hormones are the body's chemical messengers. They carry information and instructions from one set of cells to another"

Answer:

b have a good day

Explanation:

Why did the accepted scientific theory of the solar system change from a geocentric model with Earth in the center to a heliocentric model with the Sun in the center?

Question 2 options:

A: Because over time the Sun's position changed


B: Because over time the Earth's position changed


C: New evidence and observations changed our understanding of the solar system


D: New planets formed in between the Sun and Earth

Answers

I think it is A and C sorry if I’m wrong

All of the following are true about thymine dimers EXCEPT: the type of repair that is done to fix them is called nucleotide excision repair they are caused by UV radiation damage that fuses thymines that are next to each other on the same strand individuals with xeroderma pigmentosa (XP) are unable to repair this type of DNA damage, leading to cancer cell development they are caused by UV radiation damage to thymines that are opposite each other on different DNA strands

Answers

Answer:

Option 4, they are caused by UV radiation damage to thymines that are opposite each other on different DNA strands

Explanation:

Thymine dimer is formed on adjacent thymine and hence they lie next to each other on the same strand. They do not lie on strand that are opposite of  each other on different DNA strand.

Hence, option 4 is correct

PLEASE HELP!!! Will give brainliest!!


What is the function of glycoproteins?

A) to serve as identification for the cell

B) to allow specific ions or molecules to pass freely

C) to detect bacteria and other foreign bodies outside of the cell

Answers

Answer: Cell-cell recognition, cross-linking of cells and proteins give strength and stability to the cell

Helps in intercellular communication

Some hormones are glycoproteins

Blood clotting proteins are glycoprotein in nature like thrombin, prothrombin

Mucin glycoprotein found in mucus

It is important for reproduction, because they help in sperm-egg recognition

Immmune system relies on glycoproteins

What two nations were at the center of the Space Race in the 1950's Australia and Russia .China and United States .United States and Russia .
Russia and China​

Answers

Answer:The Space Race was a 20th-century competition between two Cold War adversaries, the Soviet Union (USSR) and the United States (US), to achieve superior spaceflight capability.

Explanation:

i looked it up

The two nations that were at the center of the Space Race in the 1950s should be considered  Russia and China.

What is Space Race?

The Space Race was the competition held in 20the century that lies between the two Cold War adversaries i.e. soviet union and the united stated for accomplishing the superior spaceflight capability.

Also, it has its origin in the ballistic missile that based on the nuclear arms race.

Learn more about the nation here: https://brainly.com/question/365702?referrer=searchResults

10.) What hormone is released due to the rising level of estrogen in the bloodstream?​

Answers

Answer:

10.) What hormone is released due to the rising level of estrogen in the bloodstream?

A) When the level of estrogen is sufficiently high, it produces a sudden release of LH, usually around day thirteen of the cycle.

-TheUnknownScientist

Answer:

LH hormone is released due to the rising level of estrogen in the bloodstream.

please help me with this ​

Answers

Answer:

Question 13 : Ureter

Question 14 : Ovulation

Explanation:

..........................

Answer:

the answer is ovulation

A big, powerful male gorilla is much more likely than a smaller, weaker
gorilla to become the population's silverback, the pack's leader who mates
far more than the other males of the group. The pack leader will, therefore,
father more offspring, who share half of his genes, and are thus likely to also
grow bigger and stronger like their father. Over time, the genes for bigger
size will increase in frequency in the population, and the population will, as a
result, grow larger on average.
Determine the Mechanism of Evolution observed in the Scenario:

Answers

Answer:

9it is not evolution but it is actually a dominant trait being passed down

Explanation:

Giving away 17 points!! Please help me ASAP!!!

Answers

Answer:a major ecosystem defined by distinctive geography and receiving uniform solar radiation and moisture.

Explanation:

answers to ten and tweleve please giving brainlist

Answers

Answer:

A and D

Explanation:

the Calvin cycle in photosynthesis doesn't need sunlight and this worksheet seems to focus on energy from the sun and how it is used in plants

Which bones make your gesture posture straight

Answers

Answer:

Your hamstring and your back muscle keeps your posture straight.

Explanation:

Answer: hamstrings and large back muscles

Which of the following is NOT a way to prevent the spread of infectious disease?
A. Get vacinated
B. Rinse dirty cutting boards with cold water
C.Don't share personal items
D.Wash your hands

Answers

Answer: I think B

Explanation:

In the logistic growth model, as a population approaches the carrying capacity, what happens to its growth rate?
A
becomes exponential

B
doubles

C
increases

D
slows to zero

Answers

I am pretty sure it is D slows to zero, don’t get mad at me if I’m wrong I’m pretty sure I am correct though.

In the logistic growth model, as a population approaches the carrying capacity, the growth rate of the population will slow down to zero. Thus, the correct option is D.

What is Logistic growth model?

The logistic growth model is a parameter which represents the rate at which the population would grow if it were unencumbered by the environmental degradation. A second parameter, that is K, represents the carrying capacity of the system of species which are being studied.

In logistic growth, a population's per capita growth rate gets smaller and smaller as the population size when it approaches a maximum imposed by the limited resources in the environment, known as the carrying capacity (K). Exponential growth model produces a J-shaped curve, while logistic growth produces an S-shaped curve.

Therefore, the correct option is D.

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The original base sequence of DNA is : CAG TTA CCA. If the amino acid sequence that results from translation of this DNA base sequence is: valine-tyrosine-glycine, what mutation occurred in the DNA? Explain
A. An addition mutation occurred
B. A deletion mutation occurred
C. A substitution mutation occurred
D. A mutation did not occur.

Answers

C

I think substitution, because the original translation of the original base sequence is glutamine-leucine-proline. The base sequence for valine-tyrosine-glycine is: GT#  TA#  GG# . of course the last codon is unclear, but the first two gives us enough to know too much change happened for a simple addition or deletion mutation. The bases were completely switched out, therefore it is a substitution mutation. I attached a codon chart.

If a pet has to survive without your care, how would its diet change? Write your ideas on the lines below. Read about how organisms get food and energy in their environment

Answers

Answer:

rather than consuming "pet food" that contains all proper nutrients required your pet would being to scavenge for food wherever they could find it. Survival instincts would kick in and they would eat whatever they could find. Depending on food availability, loss of muscle mass is a possibility.  

Explanation:

If my pet is to survive without me, its diet will change. First of all, he will not get food, so how is it possible for a living being to survive without food. It will get skinny and starve to death after a few days.

What is Diet?

Diet is defined as the sum of food that is consumed by a person or other organism. The term diet refers to the use of a specific intake of nutrition for health or weight-management reasons. Humans are omnivores so, every culture and every individual has some food preferences or some food taboos.

It is essential for good health and nutrition protects you from many chronic non-communicable diseases like heart disease, diabetes and cancer. Eating a variety of foods and consuming less salt, sugar, and saturated and industrially produced trans-fats are important for a healthy diet.

Thus, if my pet is to survive without me, its diet will change. First of all, he will not get food, so how is it possible for a living being to survive without food. It will get skinny and starve to death after a few days.

Learn more about Diet, here:

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HELPPP PLS i need helppp

Answers

Answer:

is this a genetic diagram u need to be filled out or nah?

Which biome receives the most rain?

tropical rain forest
temperate rain forest
taiga
tundra

Answers

Answer:

do not know

Explanation:

Answer:

answer is A

tropical rain forest

Explanation:

got it right!

hope this helps

 The Asthenosphere is part of which layer of the Earth?

Answers

Answer:

Earth's mantle

Explanation:

Asthenosphere, zone of earth's mantle lying beneath the lithosphere and believed to be much hotter and more fluid than the lithosphere

Locations in California are warmest in summer because sunlight in summer is

A) least intense and of shortest duration
B) least intense and of longest duration
C) most intense and of shortest duration
D) most intense and of longest duration

Answers

D most intense and longest duration is the answer

why is one mutation not enough to result in cancer​

Answers

Answer:

A single mutation is unlikely to result in cancer. Cancer is usually caused by a series of mutations that accumulate throughout the course of a person's life. As a result, cancer is more common in older adults. They've seen more chances for mutations to accumulate.

Explanation:

Change to ecosystems occurs both slowly and quickly.
True
False

Answers

True
Drastic biological events may happen such as a volcano eruption or a hurricane. It can also happen overtime. For example, a species dying off due to lack of food and/or global warming.

Please help I’ll mark you as brainliest if correct

Answers

Answer:

J six

Explanation:

If the gene for purple flowers is dominant and two white flowered plants produce 6 offspring, then the answer must be 6. Every life form with genes has a dominant and recessive gene. For example, on a child’s fathers side there is a history of large ears. On the child’s mothers side there is a history of small ears. The father’s large ear size is dominant, so the child will have large ears. If two white flowers are white instead of purple that must mean that the dominant purple gene was not in their flower history. Therefore, their offspring will have no chance of developing a purple colour.

Drag each label to the correct location on the table. Sort the observations based on whether they are quantitative or qualitative.

Answers

Answer:

Qualitative observations are those that cannot really be counted or measured by empirical figures, but are rather described by the features they have such as their color or taste.

Quantitative observations can be measured and counted by empirical figures  i.e. numbers such as age and temperature. Number operations such as addition can be performed on them as well.

Qualitative observations.

The shirt is soft  and red.The river flows more  quickly in the spring  than in the summer.

Quantitative observations.

There are eight elephants  over the age of six  at the zoo.   It is 72 degrees  Fahrenheit outside.

Answer:

Quantitative observation:

There are eight elephants over the age of six at the zoo.

It is 72 degrees  Fahrenheit outside.

Qualitative observation:-

The shirt is soft and red.

The river flows more quickly in the spring than in the summer.

What is the relationship between aquifers and porosity?

Answers

Answer:

The pore space of an aquifer is the spaces or voids between the solid material. The porosity of the aquifer is the volume of void space to the total volume, typically expressed as a percentage.

PLEASE HELP !! ILL GIVE 40 POINTS ; PLUS BRAINLIEST !! DONT SKIP ANSWER.

Answers

Answer: yo what grade is u in for these people to give you advanced word like this and also the letters are too small for me to see so I can't solve it right away.

Explanation:

Answer:

B

Explanation:

Producers, consumers, and decomposers play important roles in the environment. Are there any organisms that would not fall into one of these categories? Explain your answer.

Answers

Answer:

No, there are no organisms that will not fall into these categories

Explanation:

Living organisms interact with one another in their natural environment in order to ensure that energy needed for their metabolic activities is obtained. To do this, each organism plays different or specific roles. The roles that every organism must fall into are as follows:

- Producers are groups of organisms that have the ability to synthesize their own food using light (photosynthesis) or chemicals (chemosynthesis). Examples are green plants, algae, some bacteria etc.

- Consumers- These are organisms that lack the ability to synthesize their own food and hence depend on other organisms for their energy source. Consumers can either be herbivores (eat plants) or carnivores (eat flesh) etc. Examples are all animals etc.

- Decomposers- These are organism that have the ability to breakdown dead organisms into organic matter, thereby, adding nutrients back to the soil. Examples are fungi, bacteria, earthworm etc.

Based on this explanation above, no organism will not fall into any of these three categories. Some can even occupy two roles.

SLO-4.2. Within all tissues in the body, there are stores of undifferentiated cells that can become any specialized type of cell in that tissue for the purpose of growth and healing. Today, Regenerative Medicine is trying to employ these cells to replace tissues that have been destroyed by disease and trauma, such as spinal cord injuries. What are these cells

Answers

Answer:

These cells are stem cells.

Explanation:

Stem cells have not specialized to be in a specific tissue and have a particular function yet. They are the cells that give all the different cell types that our body has. In other words, they can become any cell type that the body needs. We call them pluripotent cells because they have the potential of becoming any specialized cell.

Scientists use stem cells in tissue or organ regeneration due to the pluripotential that they have.

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reduse this fractions 4/8 and 6/10 Much of Europe before 1914 had prided itself on the relative legal security and stability that many of its states provided for their citizens . . . One of the novelties of the February Revolution in Russia in 1917 was that the pressures of war led to the first major crack in this system, soon to be followed by its complete implosion . . . it was defeat in the Great War, and the collapse of the pre-war system, that allowed new actors to compete violently for power, generally without the relative restraint that had characterized social and political conflicts prior to 1914.Robert Gerwarth, The Vanquished: Why the First World War Failed to End. 2016According to Gerwarth, how did World War I facilitate the rise of violent new regimes?A. The establish of the Soviet Union helped Communism spread across EuropeB. The war destroyed a stable order in Europe, opening the door for new movementsC. The defeated powers hungered for revengeD. 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This can be anything that you enjoy doing or have to do. Playing sports, taking a jog, walking the dog, and doing yard work are some examples.Second in the text box write two-four complete sentence describing what you did. What did you do? When did you do it? Where did you do it? Was it easy? Is this something that you normally do? How long did it take? Did someone do it with you? The table shows Linda's monthly expenses . Which list shows the expenses in order from greatest to least amount of the monthly budget?TABLE: Utilities: 13%Rent: 43/100Food: 1/10Car: 27%Other: 0.07ANSWERS:A: other, food, utilities, car, rentB) rent, car, utilities, food, otherC: food, other, utilities, car, rentD: car, rent, food other utilities Suppose Kevin and Maria are playing a game in which both must simultaneously choose the action Left or Right. The payoff matrix that follows shows the payoff each person will earn as a function of both of their choices. 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