single-cell rna-sequencing reveals widespread personalized, context-specific gene expression regulation in immune cells

Answers

Answer 1

A single population's stochastic changes in gene expression that may be responsible for complicated immunological responses can be found using scRNA-seq.

In order to determine the cell fate choices made by various cell subpopulations, developmental "trajectories" can be reconstructed using scRNA-seq.Identification of novel cell types and gene regulatory networks, as well as analysis of the kinetics of gene expression and patterns of allele-specific expression, are all made possible by single-cell RNA-sequencing (scRNA-seq).Different immune cell subsets can be recognised and characterised in health and disease using single-cell RNA sequencing (scRNA-seq). These immune cells' transcriptional fingerprints make it possible to identify new pathogenic drivers and biomarkers.

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Related Questions

To be effective at helping the sugar from the blood move into the cells, insulin (which is a protein) should be taken orally sublingually by injection sub-Q (subcutaneously - under the skin), by injection IM (into the muscle).

Answers

To be effective at helping the sugar from the blood move into the cells, Insulin should be taken BY INJECTION SUB - Q (SUBCUTANEOUSLY - UNDER THE SKIN) .

Your pancreas secretes the hormone insulin, which regulates the level of glucose in your bloodstream at any given time. It also aids in the storage of glucose in your muscles, fat, and liver. Finally, it controls how proteins, lipids, and carbs are metabolized by your body. Sound significant? That is true, after all.

"Your body cannot produce any fat or store glucose in your muscles or liver without normal insulin activity. An endocrinologist, claims that the fat actually breaks down and creates keto acids among other things. If these acids' concentrations rise too high, a potentially lethal disease known as diabetic ketoacidosis may result from the imbalance. Many diabetics who take insulin inject it into themselves using a syringe. Lines on the outside of the syringe indicate how much medication is in the needle. With the assistance of your doctor, you can select from a variety of syringe sizes.

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Amino acids are used to build

Answers

Answer:

Proteins

Explanation:

The building blocks of proteins are amino acids

diagram 1 depicts . during this part of ventilation, the rib cage moves , pressure in the lungs , and air is pushed . the diaphragm and moves down.

Answers

In inspiration, during this part of ventilation, the rib cage moves up, pressure in the lungs decreases, and air is pushed into the lungs. The diaphragm contracts and moves down.

The human respiratory system refers to an efficient system of inspiring and expiring respiratory gases that occur in the lungs. Inspiration or inhalation refers to the process of taking air into the lungs. It is the active phase of ventilation as it occurs as the result of muscle contraction. During inspiration, the diaphragm contracts and pull downward. The thoracic cavity increases in volume and pressure in the lungs decreases. This decreases the interalveolar pressure so that air flows into the lungs.

Note: The question is incomplete. The complete question probably is: Diagram 1 depicts inspiration. During this part of ventilation, the rib cage moves up, pressure in the lungs ________, and air is pushed into the lungs. The diaphragm ________ and moves down.

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22. What is the central iden of "A Brief History of DDT"?
ects. but its harmful effects led to limited use.
B. Rachel Carson was attacked by the chemical Kennedy defended her.
C. Pesticides such as DDT cause liver tumors in mice and cancer in humans.
D. If it hadn't been for Rachel Carson, farmers would still be spraying their crops with DDT:

Answers

Pesticides such as DDT cause liver tumors in mice and cancer in humans.

what is DDT ?

The first of the current synthetic pesticides, DDT (dichloro-diphenyl-trichloroethane), was created in the 1940s. Malaria, typhus, and other human illnesses spread by insects were the first to be successfully treated with it in both military and civilian populations. Additionally, it worked well to control insects in houses, institutions, gardens, dwellings, and crop and livestock production. Due to DDT's widespread usage and early effectiveness as a pesticide in the US and other nations, many insect pest species have developed resistance to it.

DDT is:

a substance that is known to be extremely persistent in the environment, builds up in fatty tissues, and

in the high atmosphere, may travel great distances.

Although the concentration of DDT in the environment and animals has dropped since it was no longer used in the United States, residual danger from earlier usage is still present due to its persistence.

Concerns about hazards to the environment, wildlife, and public health led to the EPA's 1972 prohibition. A possible causal link between DDT exposure and reproductive impacts is also postulated.

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Plant tissues are made of three basic types of cells: parenchyma, collenchyma and sclerenchyma.
Which of the following statements is true about all plant cells:
O They do not have nucleus
O They do not have a cell membrane
O They have a cell wall
O They have the same functions

Answers

Answer: The following statements are true about plant cells-

-They have a cell wall

-They have the same functions

Explanation:

A cell wall is present in a plant cell to keep its structure and rigidity. They are made from cellulose.

All plant cells have a nucleus, ribosomes, mitochondria and cell membrane and they all have the same functions as they would have in an animal cell.

Statement 1 is false as plant cells are eukaryotic, which means they have a nucleus.

Statement 2 is also false because a plant cell needs a cell membrane to separate the vacuole and the organelles.

Hope that helped :)

. In the picture below, in which direction will water move?

into the cell
out of the cell

Answers

Answer: into the cell

Explanation:

what is an omnivore and a carnivore and herbivore

Answers

A carnivore is a animal that eats meat a herbivore is a animal that eats plants and a omnivore is a animal that eats both mean and plants

which the following sexual transmitted infections (stis) has a long asymptomatic latent phase characteristic?

Answers

Syphilis is a sexual transmitted infections (STI) has a long asymptomatic latent phase characteristic.

Syphilis Causes and Symptoms

Syphilis is caused by a bacterial infection Treponema pallidum which is spread through sexual contact with lion king sufferers. The syphilis-causing bacteria can also be spread through physical contact with wounds on the sufferer's body.

Symptoms of syphilis are classified according to the stage of development of the disease. Each type of syphilis has different symptoms. Here is the explanation:

Primary syphilis

This type of syphilis is characterized by sores (chancres) where the bacteria enter.

Secondary syphilis

This type of syphilis is characterized by the appearance of a rash on the body.

Latent syphilis

Syphilis does not cause symptoms, but the bacteria are present in the patient's body.

Tertiary syphilis

Syphilis can cause damage to the brain, nerves, heart or other organs.

Syphilis Treatment and Prevention

Treatment of syphilis will be more effective if done at an early stage. During the treatment period, sufferers are advised not to have sex, until the doctor makes sure the infection has healed.

Syphilis can be prevented by practicing safe sex, namely being faithful to one sexual partner and using a condom every time you have sex. In addition, examination or screening for syphilis also needs to be carried out routinely for people who are at high risk of experiencing this disease.

Your question is incomplete but most probably your full question was:

Which the following sexual transmitted infections (STIS) has a long asymptomatic latent phase characteristic?

a. Gonorrhea

b. Syphilis

c. Chlamydia

d. Hepatitis B

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one predator avoidance mechanism that has evolved in prey is secretion of enzymes that break down toxic plant compounds. development of a short gestation period. chemical defenses and bright coloration. secretion of digestive enzymes that hydrolyze glucose.

Answers

One predator avoidance mechanism that has evolved in prey is secretion of enzymes that break down toxic plant compounds is chemical defense.

Predation makes all the people withinside the populations being preyed upon much less fit. Predation does not have any long time results on prey organisms. Predation will make prey organisms wait longer to reproduce. The best-recognized examples of predation contain carnivores interactions, wherein one animal consumes another. Think of wolves looking moose, owls looking mice, or shrews looking worms and insects. Less apparent carnivorous interactions contain many small people eating a bigger one.

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The approach that uses information from genome projects to understand genetic variation among different populations is called ______________ genomics.

Answers

Answer:

Comparative

Explanation:

I hope this helps!!!

This makes up the ribosomal subunits and reads the mRNA.

a. ribosome

b. rna polymerase

c. rRNA

d. tRNA

e. mRNA

Answers

tRNA makes up the ribosomal sub units and reads the mRNA as it is made up of two sub units where the mRNA is attached to the lower unit and it reads the mRNA that is doing proof reading as well.

What is the full form of tRNA ?

The full form of tRNA is transfer RNA.

Ribosome is the unit of the cell that is responsible for the protein synthesis and these make up the cells' proteins.  rna polymerase is responsible for synthesising the RNA strand and continuing the synthesis.

tRNA is the transfer RNA that containsw the two ribosomal subunits where the two of the units are joined together and on the lower unit is the mRNA attached to which the amino acid synthesis take place and that reading is done by the tRNA is done in order to check the pattern as per the instructions.

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For which of the following conditions would you MOST likely encounter a ventricular peritoneum shunt?

Answers

you MOST likely encounter a ventricular peritoneum shunt in hydrocephalus.

Another way to treat hydrocephalus is ventriculopleural diversion (VPLS), which diverts additional cerebrospinal fluid into the pleural space. Pleural effusion develops and accumulates as a result of an imbalance between CSF production and absorption.

How long does a ventriculoperitoneal shunt last?

After several years, especially in younger children, the VP shunt may need to be replaced. The life expectancy of a newborn shunt is her two years. Adults or children 2 years and older may not need shunt replacement for 8 years or longer.

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Discuss how crossing-over leads to greater variability of phenotypes. list when and where it occurs in your answer.

Answers

The exchange of chromosomal segments between nonsister chromatids during meiosis is known as crossing over or recombination. Genetic diversity is increased by the cross-over of novel gene combinations that do not exist in either parent in the gametes.

Where does the crossing take place?

When homologous chromosomes are fully coupled during the pachytene stage of meiosis, crossing-over takes place. Chiasmata, which retain the two homologs of a bivalent together until segregation at anaphase I, are apparent as the sites of crossing-over at diplotene, when homologs split.

To boost genetic variety, a process called crossing over takes place between homologous chromosomes. An exchange of chromosomal segments occurs during crossing over. The outcome is a hybrid chromosome with a distinctive genetic material pattern.

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When genetic and environmental effects contribute independently to phenotype, the total variance equals the ________________ of the genotypic variance and the environmental variance.

Answers

When genetic and environmental effects contribute independently to phenotype, the total variance equals the Sum of the genotypic variance and the environmental variance.

What is genotypic variance ?Genotypic variation, which results from genetic mutation, gene flow, or anything that happened during meiosis, is the variance in genotypes between individuals of the same species or between species.The English biologist and statistician Ronald Fisher introduced the idea of genetic variance in his foundational theorem of natural selection.Phenotype:

The term phenotype describes an individual's observable characteristics, such as height, eye color, and blood type. Both a person's genomic make-up (genotype) and environmental circumstances affect their phenotype.

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In the cell, the site of oxygen utilization is the
a) nucleus.
b) chloroplast.
c) endoplasmic reticulum.
d) mitochondrion.
e) cytosol

Answers

The correct option is (d) mitochondrion, the site of oxygen utilization in the cell.

The fundamental structural and operational unit of all living things is the cell. A variety of macromolecules, such as proteins, DNA, and RNA, as well as a large number of small molecules that constitute nutrients and metabolites are found in each cell's cytoplasm, which is encircled by a membrane. The word cellula, which means "small apartment" in Latin, is where the phrase gets its name. Protein synthesis, DNA repair, replication, and motility are just a few of the operations that cells can carry out internally in addition to developing specialized capabilities. Cells can migrate around and specialize within the cell. Most cells are measured in micrometers due to their tiny size. The bulk of plant and animal cells, which range in size from 1 to 100 micrometers, can only be seen under a light microscope. An extremely detailed cell structure can be seen with electron microscopy, which has a much better resolution. Unicellular (consisting of just one cell, like bacteria) and multicellular are the two categories of creatures (including plants and animals). The bulk of unicellular creatures are microorganisms.

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6. The drawings below represent three different birds. The beak shape makes it easy for
each bird to obtain food in a different way.
The differences in beak shape are examples of
(1 point)
0000
camouflage
dynamic equilibrium
competition
biological adaptation

Answers

The differences in beak shape are examples of the biological adaptation of the birds to obtain food.

What is biological adaptation?

Biological adaptation is a characteristic of an organism's phenotypic traits in relation to environmental selection pressures. Adaptive features are those that have form and function characteristics that enable the organism to successfully sustain the synergy between a feature's biological purpose and a stated selection force. The quantity of energy required to sustain the synergy can be used to gauge how well an adaptation is working, with lower energy requirements suggesting better adaptation.

What is a beak?

An external anatomical feature called the beak, bill, or rostrum is usually present in birds but can also be seen in turtles, non-avian dinosaurs, a few mammals, and other animals. To eat, groom, manipulate things, kill prey, battle, probe for food, court, and feed young, an animal uses its beak.

Hence, the differences in beak shape are examples of the biological adaptation of the birds to obtain food.

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Which of the following is the best explanation of why it is difficult to discriminate the color of an object at night?
Rods contain a single kind of visual pigment.
Cones come in three types, each sensitive to different wavelengths of light.
The foveae are densely packed with cones.
As many as 100 cones may converge on one ganglion cell.

Answers

The response is A. Cones occur in three varieties, each of which is sensitive to a particular range of light wavelengths.

Cones are the three different types of light-detecting cells found in the eyes. Green is the color that is easiest to notice throughout the day because light & color travel in waves.

Several of the cones are "less active" in the absence of daylight, which makes colors harder to discern. As a result, yellow is easier to notice at night since there is less light to aid in color perception.

Cone and rod cells can be found in the retina. We can see in low light thanks to our rod cells, and we can perceive color thanks to our cone cells.

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A gene is the information required to make an RNA or protein product, a(n) ______ is a variant version of a particular gene.

Answers

A mutation is a different version of a specific gene, whereas a gene is the information needed to create an RNA or protein product.

What are genes, and what do they do? Is a gene an RNA segment that helps make proteins?

A gene is a region of DNA needed to make a single protein. Since genes contain the genetic information for proteins consisting of hundreds or thousands of amino acids, they are often hundreds or thousands of base pairs long. The instructions needed to create the useful molecules known as proteins are found in the majority of genes.

What do you name a gene variant?

Depending on where they occur and whether they change the way that critical proteins operate, gene variations, also known as mutations, can have different implications on health.

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Which of the following can be a challenge when implementing a green space? (1 point)
O making sure no buildings are around it
O making sure there are enough sidewalks
O making sure it is not shaded
O making sure access is equitable

Answers

Answer: D.  making sure access is equitable

Explanation:  When implementing a green space, one of the challenges can be ensuring equitable access. It is important to make sure that the green space is easily accessible to all members of the community, regardless of their location or socioeconomic status. This can involve factors such as the proximity of the green space to residential areas, public transportation options, and the presence of sidewalks or pathways that allow people to reach the green space safely.

What is meant by the net movement of particles

Answers

Answer:  The number of the molecules moving in the direction of the forces minus the number of the molecules moving in other direction

Explanation:  The number of the molecules moving in the direction of the forces minus the number of the molecules moving in other direction is the net movement of the molecules.

Explanation:

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find the p-wave that travels the distance below

Answers

In order to be able to complete the above task, that is, deriving the time taken for the P-wave to travel the distances given, further information is required such as a graph showing the time-distance graph. See the example attached.

What is an example showing how to derive the distance traveled by a p-wave?

For example, the accompanying graph shows that if the epicenter of an earthquake is 4000 kilometers away, the P-wave will arrive 7 minutes later. That means the first tremors will be felt at your position 7 minutes after the rupture at the epicenter.

Remember that P-waves are one of the two primary forms of elastic body waves, often known as seismic waves in seismology. Because P waves move quicker than other seismic waves, they are the first to reach at any afflicted area or seismograph following an earthquake. P waves may travel through gases, liquids, and solids.

A P-wave's velocity can be represented as:

P wave velocity = ((B + 1.3G)/Density)1/2,

where:

B is the bulk modulus, which is the resistance to volume change; and G is the Shear modulus, which is the resistance to form change.

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The energy required for the chemical reaction of 21.7 grams of nitrogen to produce ammonia is
kilojoules.

Answers

The energy required for the chemical reaction of 21.7 grams of nitrogen to produce ammonia is -71.1 KJ/mol.

What is a chemical reaction?

A chemical reaction is the process which involves a change in the chemical composition of compounds. It involves formation of new chemical bonds between atoms.

In this case, since the formation of ammonia by starting with nitrogen and therefore hydrogen is:

N₂ + 3H₂ ⇒ 2NH₃

This chemical reaction has energy:

ΔfH(NH₃) = -45.90 KJ/ mol

We can compute the energy required for this chemical reaction by first computing the moles of ammonia yielded by 21.7 grams of nitrogen (28.02 g/mol) via stoichiometry:

nNH₃ = 21.7 N₂ × 1 mol N₂/ 28.02g N₂ × 2 mol NH₃/ 1 mol N₂ = 1.55 mol NH₃

Thus, the energy turns out:

Q = n NH₃ ΔfH(NH₃) = 1.55 mol NH₃ × -45.90 KJ/ mol

Q = -71.1 KJ

Hence, the ΔH of the chemical equation will be = -71.1 KJ/mol

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which of the following is classified as an insoluble fiber? A. mucilage B. cellulose C. pectin D. gums

Answers

The insoluble fiber is cellulose that is option B.

What is cellulose ?

Plant cell walls are composed of cellulose, a type of fiber. You ingest cellulose when you eat plant-based meals. The addition of cellulose helps many other foods with various features, from reduced calorie or diet foods to shredded cheese. There are supplements that contain cellulose.

The body cannot digest cellulose because it is an insoluble form of fiber. When you consume a piece of celery, its other nutrients are digested, but the cellulose passes through your system undigested. Your health gains from this in a number of significant ways.

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Which of the following is a characteristic of cell communication that suggests cell signaling evolved early in the history of life?a. All organisms form cell junctions to allow transfer of signaling molecules.b. All organisms produce hormones to carry out signaling processes.c. Plants, animals and bacteria share very similar signaling processes.d. Plants, animals and bacteria use long - distance signaling molecules.

Answers

Plants, animals, and bacteria share very similar signaling processes is a characteristic of cell communication that suggests cell signaling evolved early in the history of life.

The fundamental design of the signaling pathways is fairly similar in all of these organisms. The extracellular domain of the receptor is where signalling molecules often attach, causing certain conformational changes in the receptor that result in the creation of secondary messengers inside the cell, which in turn cause more adaptor molecules and transcription factors. All of these cellular internal alterations cause the transcription or chemical synthesis of the necessary enzymes, which aid the cell in responding to the signal.As a result, this characteristic of cell communication suggests that cell signalling evolved early in the course of life.Not every organism makes hormones for cell signalling. The majority of higher organisms, such as animals and plants, have access to hormones. There is no cell signalling hormone produced by bacteria. Thus, it is not a characteristic either.

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help me please hurry up fr :(

Answers

Answer:

Ex3. The top squares are both Tt and the bottom squares are both tt. The probably of the offspring being a homozygous recessive is 50%.

Ex4. The difference between phenotype and genotype is that genotype is the exact genetic information while phenotype is the observable trait of the organism. For the example above, the genotype would be the Tt and tt while the 2 phenotypes would be showing the dominant or the recessive.

Explanation:

please help Conduct online research on a coastline nearby or any coastline of your choice and describe the geological process of the coastline. Add a note on how these features affects the lives of people living in the area.

Answers

Seacoasts are land. Coastlines are where land meets water. Waves, tides, and currents form coasts. Waves degrade land.  For example: Great Ocean Road, Australia.

What is a coastline?

The coastline is the area of a shoreline where land and water converge. Coastlines are shaped in part by currents, tides, and waves. The ground is eroded or worn away when waves crash upon the shore.

Coastal regions can be divided into four categories: emergent, submergent, discordant, and concordant. Submergent beaches have sunk below the water, while emerging coastlines have protruded from it.

Beaches, mudflats, cliffs, and caverns are just a few of the many varied characteristics of coasts. These coastal characteristics are shaped by tides, waves, and water currents (flow). Glaciers, which are massive rivers of ice, and volcanic lava flow both alter some beaches.

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If your instructor asked you to trace the process of urine formation, which of the following identifies the steps in the correct order?
Glomerular filtration occurs first and then reabsorption and secretion occur simultaneously

Answers

Three phases are involved in the production of urine: Glomerular filtration occurs through the semipermeable and glomerulus and glomerulus capsule.

What are the four steps in the creation of urine?

Plasma is the first step in four fundamental procedures that create urine.

Filtration.

Reabsorption.

In the distal tubule and collecting duct, hormones regulate reabsorption, regulating the pace at which sodium and water are transported based on systemic circumstances.

Secretion.

Excretion.

Give a brief description of each of the four urinary tract structures?

Organs that filter blood to produce urine include two kidneys. the organ that houses the bladder and stores urine. Your two ureters, or tubes, join your kidneys and bladder. the tube that joins your bladder to the outside of your body, the urethra.

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Genes contain the keys for constructing
purines
nucleosomes
proteins
pyrimidines

Answers

Answer:

proteins

Explanation:

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Answer: The answer is C. Proteins

Explanation:

HELPPPP PLS: Give an example of how the lack of sunlight can affect interactions between living/non-living things.

Answers

The interaction between living things and non-living things can be seen in a situation where a lack of sunlight affects the rate at which evaporation of water which results in rainfall cannot occur, and plants and animals are unable to obtain water for their growth and metabolism.

What are living and non-living things?

Living things are things that have life in them. They include plants and animals. The characteristics of life that living things possess include:

movementrespirationnutritionreproductiongrowthexcretionIrritability

Non-living things are things that do not have life in them. Examples of non-living things include rocks, water, and gases.

Living things and non-living things interact with each other in the environment.

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Taigas, tundras, and tropical rainforests share what common abiotic component?
Responses

freezing temperatures
freezing temperatures

a lot of sunlight
a lot of sunlight

nutrient-poor soil
nutrient-poor soil

little precipitation

Answers

Answer:

A lot of sunlight

Explanation:

Although taigas and tundra's have colder climates, they receive a lot of indirect sunlight. Tropical rainforests receive a lot of sunlight as well.

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